relation: http://miis.maths.ox.ac.uk/miis/339/
title: A Mechanism for Ventricular Expansion in Communicating Hydrocephalus
creator: Begg, R.
creator: Wilkie, K.
subject: Medical and pharmaceutical
description: This report investigates a new possible molecular mechanism for the pathogenesis of hydrocephalus. New research by Dr. Miles Johnston has found that the injection of anti beta_1 integrin antibodies into the ventricle of rats causes a drop in parenchymal pressure and causes the cerebral ventricles to enlarge which is characteristic of hydrocephalus. We investigate intramantle pressure gradients as a possible force to enlarge the ventricles and we propose a new poroelastic model incorporating the effect of the antibodies to determine if they are a possible mechanism for hydrocephalus.
date: 2009
type: Study Group Report
type: NonPeerReviewed
format: application/pdf
language: en
identifier: http://miis.maths.ox.ac.uk/miis/339/1/Hydrocephalus.pdf
identifier:   Begg, R. and Wilkie, K.  (2009) A Mechanism for Ventricular Expansion in Communicating Hydrocephalus.  [Study Group Report]